POTENTIAL "ANTIBIOTICS" FROM FLOWERING PLANTS
Developed and Maintained by
Bioinformatics Infrastructure facility Center of Department of Biotechnology
P.G.& Research Dept. of Microbiology and Biotechnology
Presidency College(Aut.)
CHENNAI-600 005
 
 
HOME ANTIVIRALS

ANDROGRAPHOLIDE


Andrographis paniculata


Extract powder


 

Andrographolide is a labdane diterpenoid, very bitter compound and was isolated in its pure form and characterized for the first time by Gorter at 1911.

The structure of andrographolide has been analyzed by X-ray crystallographic method. Its systematic name is 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl] ethylidine]dihydro-4-hydroxy-2(3H)-furanone.


Plant source: leaves and bark of Andrographis paniculata Nees (Acanthaceae)  

Physiochemical Properties : A colourless crystalline bicyclic diterpenoid lactone,bitter substance extracted from the stem and leaves

Studies on In Vitro antiviral activity: Andrographolide inhibits the parasites at their ring stage at the IC 50 value of 9.1.

A significant rise in the mean CD4(+) lymphocyte level of HIV subjects occurred after administration of 10 mg/kg andrographolide (from a baseline of 405 cells/mm(3) to 501 cells/mm(3); p = 0.002).

Inhibit HIV-induced cell cycle dysregulation, leading to a rise in CD4(+) lymphocyte levels in HIV-1 infected individuals.( Calabrese C et al.,2000)

Studies on In vivo antiviral activity: Andrographolide –curcumin exhibited antimalarial activity by reducing parasitemia (29%) of malarial infections caused plasmodium falciparum.( Kirti Mishra, Aditya P. Dash, and Nrisingha Dey .,2011).


Genomic information: 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) gene http://www.ncbi.nlm.nih.gov/nuccore/AF389879.2 which codes for the production of HMGR enzyme is responsible for the accumulation of andrographolide.

Structure of Andrographolide

Page 1 | Page 2 | Antiviral