DATA BASE

NITROFURANS



INTRODUCTION

    • A group of synthetic antibiotics, with a new mode of action.
    • Discrimination of specific messenger RNA classes
    • Nitrofurans, a class of antibacterial drugs in extensive use, interferes with gene expression in a highly specific manner.
    • the low dose range (0.5-25 mug/ml), 5-nitro-2-furfurylidene-1-aminohydantoin has no effect on transcription, it inhibits specifically the expression of one class of genes in translation.
    • The specific inhibition concerns the inducible genes.
    • The inhibition of messenger RNA expression occurs at the initiation step.
    • The action of nitrofurans,
    • Indicates heterogeneity in the population of mRNA molecules and in the translational machinery and suggests the possibility of selective translational control.

    MEMBER OF THIS CLASS FO DRUGS INCLUDES

    • Furazolidone, antibacterial
    • Furylfuramide
    • Nitrofurantoin, antibacterial
    • Nitrofurazone, antibacterial
    • Nifuratel
    • Nifurtoinol, antibacterial
    • Nifuroxazide, antibiotic Nifurtimox, antiparasitic
    • Nifurzide, anti-infective
    For further information click the following links.

    |FURAZOLIDONE|FURYLFURAMIDE| NITROFURANTOIN|NITROFURAZONE| NIFURTIMOX|

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