INDUSTRIAL PRODUCTION OF STREPTOMYCIN

REQUIREMENTS

INTRODUCTION

  • Spores are innoculated in to the medium.
  • Obtain high mycelial biomass.
  • Introduced in to the innoculum tank.

PHASES INVOLVED

PHASE 1:
  • Rapid growth producing mycelial biomasss.
  • Little production of Streptomycin is obtained.

(Note:Proteolytic activity of the microbe releases NH3 to the medium from the soybean meal, causing a rise in pH) PHASE 2:
  • Additional production of mycelium.
  • Streptomycin accumulates in the medium.
(Note:The glucose and NH3 released are consumed during this phase.The pH remains fairly constant-between 7.6 and 8.0.)
PHASE 3:
  • Process has completed.
  • Finally the mycelium is separated by filtration and antibiotic recovesilver.